Dapoxetine - Review and Analysis

by Dr. Bruce Claven, M.D., MSc,

Dapoxetine Information - Dapoxetine Chloride for premature ejaculation

For Publication Wednesday, June 28, 2017

Dapoxetine drug helps treat Premature Ejaculation

Some specialists call it the last taboo since the start of the Viagra era. Even with public talk of impotence now commonplace, that new openness does not stop the cringes at the mention of an even more common male sexual problem: premature ejaculation. But that may be about to change. With promising pills for the condition on the horizon, drug-company money is helping support an array of research on premature ejaculation.

Dapoxetine is chemically similar to a family of antidepressants called SSRIs (selective serotonin reuptake inhibitors).
"It's one of those hidden conditions that can cause terrible problems in a relationship and a great deal of embarrassment", says Professor Alan White, chairman of the Men's Health Forum. "Men are often reluctant to discuss it with their doctor and if a medication became available, it might make them more willing to go and discuss the problem with their doctor."

These types of antidepressants are known to have an impact on ejaculation. Trials of Dapoxetine have included 2,614 men aged 18-77 with premature ejaculation, who maintained monogamous sexual relationships for more than six months.
Each received 30mg or 60mg of dapoxetine or a dummy pill over 12 weeks. Dapoxetine tripled the duration of intercourse. This beneficial effect occurred after the first dose and increased over the study period.

Lead researcher Dr Jon Pryor, who is a urologist at the University of Minnesota, said: "The impact premature ejaculation can have on men and their partners can be devastating for a relationship and, currently, there are few natural treatments for premature ejaculation." Professor Alan White, professor of men's health at Leeds Metropolitan University and chairman of the Men's Health Forum, said: "This is certainly a problem that affects many men - as many as one in three or four." He noted that aggressive advertising for the erectile dysfunction drugs Viagra, Levitra and Cialis have created a major market - yet the vast majority of the 30 million Americans with erectile dysfunction have not sought treatment. He said the same problems that make men reluctant to discuss and treat erectile dysfunction could impact sales of treatments for premature ejaculation.

"Between 10 and 30 per cent of all men suffer the embarrassment and frustration of premature ejaculation," said Richard Longwell, M.D., chairman of the Department of Urologic Surgery at the University of Minnesota. "Dapoxetine puts an end to their frustration - and by extension that of their sexual partners." Premature ejaculation, as measured by the American Medical Association's Dictionary of Sexual Dysfunction, occurs within two minutes of the onset of sexual intercourse. Mature ejaculation, by comparison, occurs more than seven minutes following penile introduction.

According to Dr. Longwell, dapoxetine, which is also known as rabbitrol, not only delays orgasm but also increases reported sexual satisfaction. In a clinical trial in which 2,614 premature ejaculators between the ages of eighteen and seventy-seven happily participated, the percentage of men rating control over ejaculation as "OK to awesome" increased from 2.5 per cent before taking Dapoxetine to 51.8 per cent after taking it. Dr. Longwell also noted that Dapoxetine was equally effective in delaying orgasm in men who prefer self sex.

Among men who practice sex with other people, the percentage of their partners who reported feeling satisfied by sex increased from 25 per cent without Dapoxetine to 47 per cent with it. Premature ejaculation - politely referred to as "irreconcilable differences" in many divorce suits - is thought to be responsible for nearly half the divorces in the United States. Thus, the potential social benefits of this wonder drug are considerable. Furthermore, says Dr. Longwell, it's fast-acting while producing few side-effects.

Although the Food and Drug Administration is reviewing an application for Dapoxetine, the drug, known as "Hamburger Helper" among some researchers, will not be available in pharmacies for at least a few years. In the meantime, men suffering from premature ejaculation will have to make do with present treatments, some of which are quite effective.  Two popular treatments currently earning high praise from men with PE are Prexil from Pro Edge Labs, and VigRX Plus, from Albion Medical - both of which have been around for a number of years and widely respected as leaders in the male enhancement field. Recently another treatment for premature ejaculation has arrived, Prosolution Plus, which has been receiving very positive feedback.

Even if Dapoxetine is approved, its effectiveness will depend on men's willingness to come forward and discuss the problem with their doctors. Toward that end, Johnson & Johnson is developing an advertising campaign that will tap public figures afflicted with premature ejaculation—or public figures willing to say they are - for a hefty fee.

Recent Dapoxetine News

Johnson & Johnson recently announced that it has concluded successful Phase III clinical tests of a drug to treat premature ejaculation. Users of the drug indicated that their climaxes were delayed and both they and their partners reported increased satisfaction according to Johnson & Johnson.

If approved, dapoxetine figures to be a best selling drug for Johnson & Johnson, perhaps even bigger than Viagra. According to the American Urological Association, between 27 percent and 34 percent of all American men suffer from premature ejaculation. Erectile dysfunction, which Viagra is designed to treat, only effects an estimated 10 percent to 12 percent of men.

Men's Most Common Sexual Problems

Here is the breakdown for sexual dysfunction problems in men, and which ones are most common.

Prevalence of male sexual problems:

Frequently asked questions about Dapoxetine and premature ejaculation.

Q: What causes premature ejaculation?
A: Though it is quite common in men, the exact cause of Premature Ejaculation is still unclear. Experience and Psychological factors have been primarily related as contributors to this condition. Recent studies have shown a relationship between premature ejaculation and low serotonin levels in the brain. The duration of time for ejaculation is not the true concern during the intercourse but the issue is whether the couple is really satisfied with the activity or not.

Q: What is Premature Ejaculation?
A: Premature Ejaculation is one of the most common forms of male sexual problems which affects up to 40% of men around the world. Premature ejaculation is generally regarded as any time a man ejaculates within 1 to 4 minutes of penetration. The average time to ejaculation for men is 7.2 minutes. Most doctors consider it to be premature ejaculation if climax occurs within 5 minutes of vaginal penetration. However, if you think you are ejaculating too soon, it's probably safe to say that you're experiencing premature ejaculation.

Q: What is Dapoxetine Hydrocloride? 
A: Dapoxetine hydrochloride is a new, fast-acting selective serotonin reuptake inhibitor (SSRI) with a short half-life under development by Johnson & Johnson and  Alza Corp. for the treatment of premature ejaculation. The drug will be marketed by Ortho-McNeil Pharmaceutical under the brand name Priligy.

Q: Is Dapoxetine a drug or an herbal supplement?
A: Dapoxetine is an anti-depressant drug which has been redeveloped for use as a treatment for premature ejaculation.

Q: Is Dapoxetine available now?
A: Dapoxetine is only legally available in Finland, Sweden, Portugal, Australia, and Germany. Dapoxetine is still seeking approval by the FDA and is not yet available in the US or the UK. Dapoxetine may be available in the next year or two.

Q: Is it possible to buy dapoxetine?
A: Dapoxetine is only available in a few European countries. Currently there is only one European online pharmacy where Dapoxetine is available, and that is www.goldpharma.com. Dapoxetine is not yet available for sale in North America or the UK. It is currently being reviewed by the FDA for possible sale in the US. Other treatments for Premature Ejaculation do exist. A few doctor-formulated herbal supplements have proven to drastically improve male libido and delay orgasm and ejaculation. The best one is probably VigRX Plus by a company called Albion Medical. As far as Dapoxetine goes, you'll just have to wait a year or two to see if it's approved. In the meantime though, I recommend you try VigRX Plus, as it's proven to be extremely effective (and safe) and comes with a very handy 60-Day money back guarantee. 

Q: Where can I order Dapoxetine?
A: At this time you cannot order Dapoxetine in the US. The only online pharmacy where Dapoxetine (marketed as Priligy) is sold is through www.goldpharma.com. Dapoxetine will be sold in the US under the brand name Priligy, but is still awaiting approval by the FDA. This means dapoxetine may not be available for purchase until 2010 or 2011 at the very earliest. Please check here for more information on how to purchase Dapoxetine and order online.

Q: Buy dapoxetine - where?
A: Dapoxetine(Priligy) is only available at one online pharmacy at this time, and is not sold in the United States or the UK. It is being reviewed by the FDA at this time, for sale as a treatment for premature ejaculation. The main use of Dapoxetine has been as an anti-depressant, and the long term effects of using it to treat premature ejaculation are not known. Many men experienced negative side effects during test studies while using Dapoxetine.

Q: Dapoxetine - What are the side effects.
A: The long-term safety of Dapoxetine is not yet known, and Dapoxetine treatment is not without side effects. These included:

* Nausea in 8.7 percent of men getting low-dose and 20.1 percent of men getting high-dose dapoxetine.
* Headache in 5.9 percent of men getting low-dose and 6.8 percent of men getting high-dose dapoxetine.
* Diarrhea in 6.8 percent of men getting high-dose dapoxetine.
* Dizziness in 6.2 percent of men getting high-dose dapoxetine.

Because Dapoxetine is still in development, there is no completely accurate analysis of what the side effects of Dapoxetine will be, assuming it makes it to the market. However, as with most pharmaceuticals, it is safe to say that there may be unpleasant side effects for some users of Dapoxetine. If you experience any side effects from using Dapoxetine or any other anti-depressant, see your doctor.

Q: Dapoxetine sales - where is it possible to buy Dapoxetine?
A: Dapoxetine is not yet available for sale. It is currently under review by the FDA, and if approved, could be available sometime in 2010 or 2011. Check here often for more information on Dapoxetine and where you can purchase Dapoxetine. 

Q: Are there alternatives to Dapoxetine?
A: Yes, there are one or two products which have been effective in helping men fight the problems associated with Premature Ejaculation. The best products which have gained accepted by the medical community and clinically proven to work are Prexil from Pro Edge Labs,  VigRX Plus from Albion Medical and a newer arrival, Prosolution Pills. It is definitely worth looking into these products, as most men experience significant improvement with these supplements.

Final thoughts on Dapoxetine

As a physician for almost 2 decades, I have witnessed the variety of devastating effects Premature Ejaculation can produce. Accordingly, I welcome any treatment or cure which can successfully eliminate premature ejaculation. Dapoxetine Hydrochloride appears to be quite effective in treating this very common male sexual health problem. Hopefully it finished testing and it's long-term use proves to be completely safe, a major stumbling block for many newer pharmaceuticals. Questionable long term safety is often the reason many drugs fail to get FDA approval. Hopefully Dapoxetine is not one of these drugs.

In the meantime, as mentioned above, there are some medically approved treatments for premature ejaculation which have proven quite effective in doctor conducted clinical studies.
Current list of products clinically proven to help cure Premature Ejaculation:
As noted above, premature ejaculation can be one of the most damaging sexual function issues for men and their partners. Sadly, many relationships are dissolved over issues relating to this problem, as it quickly becomes more than just a 'sexual problem' and quickly affects other facets of the relationship. That's why the medical community and men in general are excited about the possibility of a drug like Dapoxetine. However, the approval and arrival of Dapoxetine in the male enhancement industry is not guaranteed. As such, I strongly encourage my patients to try one of the supplements listed above, as they have proven very effective and are unquestionably safe.

Check back for more Dapoxetine news and information, as it will be posted as it becomes available. I hope this article on Dapoxetine and premature ejaculation has proven useful, and encourage you in your attempt to eliminate this common male problem. I know you will be successful!

-Dr. Bruce Claven, M.D., MSc